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Charles S Redwood Selected Research

Tropomyosin

6/2021Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
10/2020Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln147Pro Tropomyosin.
6/2020Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation.
1/2020The molecular mechanism of muscle dysfunction associated with the R133W mutation in Tpm2.2.
1/2019The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12.
12/2018The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.
12/2018The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is "freezing" of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle.
12/2017The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle.
12/2017Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene.
3/2016Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle.
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Charles S Redwood Research Topics

Disease

10Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
10/2020 - 01/2006
9Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2019 - 12/2003
6Muscle Weakness
06/2021 - 12/2017
5Muscular Diseases (Myopathy)
10/2020 - 05/2014
3Arthrogryposis
12/2018 - 03/2007
3Cap Myopathy
12/2018 - 12/2017
3Nemaline Myopathies (Nemaline Myopathy)
12/2018 - 08/2013
3Contracture
12/2017 - 03/2007
2Congenital Structural Myopathies (Centronuclear Myopathy)
06/2021 - 12/2018
2Cardiomyopathies (Cardiomyopathy)
12/2007 - 10/2003
1Heart Failure
10/2020
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
01/2019
1Aortic Valve Stenosis (Aortic Stenosis)
01/2019
1Bradycardia
11/2017
1Infarction (Infarctions)
12/2016
1familial dilated cardiomyopathy
01/2010
1Heart Diseases (Heart Disease)
12/2003
1Ischemia
12/2003
1Wolff-Parkinson-White Syndrome (Wolf-Parkinson-White Syndrome)
10/2003
1Familial Hypertrophic Cardiomyopathy (Cardiomyopathy, Familial Hypertrophic)
10/2003

Drug/Important Bio-Agent (IBA)

22TropomyosinIBA
06/2021 - 12/2003
13Myosins (Myosin)IBA
06/2021 - 09/2009
11Adenosine Triphosphatases (ATPase)IBA
06/2021 - 04/2009
8Proteins (Proteins, Gene)FDA Link
10/2020 - 10/2003
7TroponinIBA
06/2021 - 12/2007
6Troponin IIBA
12/2019 - 12/2003
5Troponin T (Troponin T1)IBA
12/2019 - 12/2003
3Troponin CIBA
08/2007 - 12/2003
2Trinitrotoluene (TNT)IBA
12/2019 - 01/2016
2CalciumIBA
12/2019 - 12/2007
2Protein Isoforms (Isoforms)IBA
12/2018 - 12/2003
2Mutant Proteins (Protein, Mutant)IBA
12/2018 - 12/2007
2Fluorescent Dyes (Fluorescent Probes)IBA
05/2014 - 08/2011
2ActomyosinIBA
05/2014 - 08/2011
1troponin-tropomyosin complexIBA
06/2021
1Actins (F Actin)IBA
06/2021
1Simendan (Levosimendan)IBA
12/2019
1omecamtiv mecarbilIBA
12/2019
1sulconazole (Myk)FDA Link
12/2019
1Carrier Proteins (Binding Protein)IBA
01/2019
1Cardiac MyosinsIBA
01/2019
1Adenosine Triphosphate (ATP)IBA
03/2016
1PerhexilineIBA
02/2015
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
03/2013
1Myosin SubfragmentsIBA
08/2011
1BuffersIBA
12/2007
1amsonic acid (DAS)IBA
03/2007
1Vanadates (Orthovanadate)IBA
01/2006
1Phosphotransferases (Kinase)IBA
10/2003
1EnzymesIBA
10/2003
1AMP-Activated Protein KinasesIBA
10/2003

Therapy/Procedure

1Endurance Training
11/2017